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Multi-target combinatory strategy to overcome tumor immune escape
《医学前沿(英文)》 2022年 第16卷 第2期 页码 208-215 doi: 10.1007/s11684-022-0922-5
关键词: immune checkpoints multi-target immune escape immune-related adverse events combination therapy
Atypical pituitary hormone–target tissue axis
《医学前沿(英文)》 2023年 第17卷 第1期 页码 1-17 doi: 10.1007/s11684-022-0973-7
关键词: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 52-60 doi: 10.1007/s11684-016-0433-3
Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P= 0.044). Kaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC-specific overall survival (HR, 2.799; 95% CI, 1.346–5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.
关键词: PPM1D hepatocellular carcinoma prognosis target therapy
Amodified variable rate particle filter for maneuvering target tracking
Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU
《信息与电子工程前沿(英文)》 2015年 第16卷 第11期 页码 985-994 doi: 10.1631/FITEE.1500149
关键词: Maneuvering target tracking Prolonged smooth regions Variable rate model Maneuver detection
Lightweight design of an electric bus body structure with analytical target cascading
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0718-y
关键词: electric vehicle body in white (BIW) lightweight analytical target cascading (ATC)
Dynamic Target Tracking of Unmanned Aerial Vehicles Under Unpredictable Disturbances
Yanjie Chen,Yangning Wu,Limin Lan,Hang Zhong,Zhiqiang Miao,Hui Zhang,Yaonan Wang,
《工程(英文)》 doi: 10.1016/j.eng.2023.05.017
关键词: Unmanned aerial vehicle Visual servoing Velocity observer Target tracking
A methodology of implementing target mixing ratio for asphalt mixture
Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG
《结构与土木工程前沿(英文)》 2017年 第11卷 第3期 页码 308-314 doi: 10.1007/s11709-017-0405-y
关键词: asphalt mixture target mixing ratio mix design implementation batching & mixing plant debugging
蒋定定,许兆林,李开端
《中国工程科学》 2004年 第6卷 第8期 页码 79-81
水面舰船识别判读是海军航空侦察工作的重要内容。文章论述了基本遗传算法(SGA)的原理、特点和运算步骤,并将该算法引入对水面舰船的识别。实验结果证明了该方法的科学性和实用性。
Moving target detection in the cepstrum domain for passive coherent location (PCL) radar
Ji-chuan LI,Xiao-de LU,Hui ZHANG,Peng-cheng YANG,Yu LIU,Mao-sheng XIANG
《信息与电子工程前沿(英文)》 2015年 第16卷 第9期 页码 785-795 doi: 10.1631/FITEE.1500036
关键词: Moving target detection Cepstrum techniques Cross ambiguity function (CAF) Passive coherent location (PCL) radar
《医学前沿(英文)》 2022年 第16卷 第4期 页码 627-636 doi: 10.1007/s11684-020-0815-4
关键词: RUNX1 gene mutation acute myeloid leukemia transcriptional repression DNA methylation
Anovel approach of noise statistics estimate using H∞ filter in target tracking
Xie WANG,Mei-qin LIU,Zhen FAN,Sen-lin ZHANG
《信息与电子工程前沿(英文)》 2016年 第17卷 第5期 页码 449-457 doi: 10.1631/FITEE.1500262
Jingde LUAN,Rundong LI,Zhihui ZHANG,Yanlong LI,Yun ZHAO
《环境科学与工程前沿(英文)》 2014年 第8卷 第6期 页码 871-876 doi: 10.1007/s11783-013-0621-1
关键词: sludge incineration heavy metals inner speciation redistribution binding energy
Ryan C. SMITH,Jinze LI,Surapol PADUNGTHON,Arup K. SENGUPTA
《环境科学与工程前沿(英文)》 2015年 第9卷 第5期 页码 929-938 doi: 10.1007/s11783-015-0795-9
Multi-UAV cooperative target tracking with bounded noise for connectivity preservation
Rui Zhou, Yu Feng, Bin Di, Jiang Zhao, Yan Hu,jzhao@buaa.edu.cn
《信息与电子工程前沿(英文)》 2020年 第21卷 第10期 页码 1413-1534 doi: 10.1631/FITEE.1900617
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 35-40 doi: 10.1007/s11684-012-0171-0
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
关键词: α7 nicotinic acetylcholine receptor cardiovascular diseases baroreflex sensitivity
标题 作者 时间 类型 操作
Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma
null
期刊论文
Amodified variable rate particle filter for maneuvering target tracking
Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU
期刊论文
Dynamic Target Tracking of Unmanned Aerial Vehicles Under Unpredictable Disturbances
Yanjie Chen,Yangning Wu,Limin Lan,Hang Zhong,Zhiqiang Miao,Hui Zhang,Yaonan Wang,
期刊论文
A methodology of implementing target mixing ratio for asphalt mixture
Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG
期刊论文
Moving target detection in the cepstrum domain for passive coherent location (PCL) radar
Ji-chuan LI,Xiao-de LU,Hui ZHANG,Peng-cheng YANG,Yu LIU,Mao-sheng XIANG
期刊论文
Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation
期刊论文
Anovel approach of noise statistics estimate using H∞ filter in target tracking
Xie WANG,Mei-qin LIU,Zhen FAN,Sen-lin ZHANG
期刊论文
Speciation evolutions of target metals (Cd, Pb) influenced by chlorine and sulfur during sewage sludge
Jingde LUAN,Rundong LI,Zhihui ZHANG,Yanlong LI,Yun ZHAO
期刊论文
support and metal oxide nanoparticles in hybrid nanosorbent materials (HNMs) for sorption/desorption of target
Ryan C. SMITH,Jinze LI,Surapol PADUNGTHON,Arup K. SENGUPTA
期刊论文
Multi-UAV cooperative target tracking with bounded noise for connectivity preservation
Rui Zhou, Yu Feng, Bin Di, Jiang Zhao, Yan Hu,jzhao@buaa.edu.cn
期刊论文